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priligy dapoxetine amazon 23, 24 Thus, the current picture suggests that increased autophagy in PDAC occurs despite the constitutive activation of ERK MAPK signalling resulting from mutation of KRAS see next paragraph constitutive activation of ERK MAPK signalling would be expected to lead to cytoplasmic retention of TFEB TFE3 due to phosphorylation by ERK MAPK2 and decreased expression of autophagy lysosome genes